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You are here: Home / Yeast Infection Treatment / Antifungal Drug Treatment / Antifungal Drug Side-Effects

Antifungal Drug Side-Effects

by Eric Bakker N.D.

All anti-fungal drugs can have the tendency to give side-effects, ranging from the mild to the extreme. Here are some of the most commonly experienced side-effects.

Topical Treatments

Topical creams and ointments may cause mild burning. Some people are highly sensitive and may have a widespread skin reaction with blisters and peeling. A number of lotions and creams also include a steroid to lessen inflammation which may trigger itchiness, irritation or dryness. Vaginal tablets do not often cause problems, but in a few women they may lead to vaginal burning or itching or skin rash. Some women experience cramps or headaches. Clotrimazole lozenges may cause minor changes in liver function, but this may not require stopping the drug.

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Oral irritation and nausea are rare side effects of Nystatin lozenges. Nystatin oral rinse (Mycostatin) is almost non-toxic, but it may cause gut problems if excessive doses are taken. Stop if you notice any side effects with topical treatments and do tell your doctor.

Systemic Treatments

Side effects for the oral azole drugs are similar, but some studies show they’re more common with Itraconazole. The most common are nausea, vomiting and belly pains. Others include dizziness, drowsiness, fever, diarrhea, headaches, rash and changes in taste. By far the most significant problem is liver toxicity, however this is uncommon and typically reverses once the medication is discontinued. Nevertheless, liver function should be carefully monitored when you commence with any pharmaceutical anti fungal, particularly with ketoconazole, ask for an LFT (liver function blood test). Don’t be afraid to ask your doctor for at least six monthly blood tests to assess your immune system, kidney and liver function.

Amphotericin B has many side effects, some quite strong and severe. Therefore, it is only used in cases when there’s a direct threat to a person’s life or all other treatments have failed. Main side effects include kidney problems and low red blood cells, known as anemia.

Others side effects include fever, chills, and changes in blood pressure, changes in appetite, nausea, vomiting and headache. These reactions occur one to three hours after an infusion, are most severe with the first few doses, and diminish with later treatments. Side effects are generally the same with all amphotericin drugs, though some forms of this drug may be slightly less toxic than others.

About Eric Bakker N.D.

Eric Bakker ND has completed almost ten years of study and has almost almost 25 years of clinical experience in natural and integrative forms of medicine, and has pursued continuous post-graduate study in Australia, America, India as well as in New Zealand.

Eric is the past Vice President of the NZ Natural Medicine Association and is currently on their editorial advisory board.

Comments

  1. Charlie says

    August 13, 2016 at 6:55 pm

    I have been taking antifungal capsules along with probiotic capsules and have developed a rash on my legs and am being attacked by scabies. Is it possible that the pills have wrecked my immune system?

    • Support says

      August 14, 2016 at 2:16 pm

      It could be interaction with other medication. Consult with your healthcare professional. It is hard to give accurate diagnosis just from a short message. But as we always say everyone’s body is different and everyone reacts differently to medication.

  2. Uzezi says

    September 27, 2017 at 11:29 am

    I have been taking antifungi drugs to cure a finger infection, the pack contains 28 tablets with just 5 more to go I started experiencing itching on my hands and foot when I took the last 2, I have 3 more to go, should I still take them or stop?

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