Zonulin is a protein made by the small bowel that controls the junction gap. The junction gap is the space between the cells lining the intestine. High levels of zonulin can mean that the junction gap is wider, and gut permeability is high. High gut permeability can result in a condition known as “leaky gut.” Leaky gut is associated with several medical conditions, including some autoimmune diseases.
If zonulin levels are very low, the gut permeability is likely low The zonulin test is usually an ELISA (enzyme-linked immunosorbent assay) blood test. Your doctor can take a blood sample to determine your zonulin level. The zonulin level indicates, with some degree of accuracy, the permeability of the small bowel.
- Candida Case Studies: Meet Jean
- Always Disconnected & Dizzy: Is It Candida?
- How Ginger Can Help against Candida?
- Benefits of Biofilms
- Can Cranberry Help Against Yeast Infections?
I’ve read some interesting studies of zonulin. One study out of Sweden showed that some people with high zonulin levels had no gastrointestinal problems. In that study, the high zonulin levels were associated with larger size.
Gluten stimulates zonulin production. One possible explanation for the study results is that heavier people may eat more gluten, resulting in higher zonulin levels even without a leaky gut.
Another interesting study demonstrated that elevated zonulin is also associated with Candida. If your zonulin levels are high, make sure you address any problems with Candida or harmful bacteria.